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These side effects are usually mild and often improve as the body gets used to the medication
It's derived from receptor adaptation kinetics measured in the SURPASS trials, where faster escalation (two-week intervals instead of four) produced 2.8 higher discontinuation rates due to intolerable nausea
Long-Term Energy Balance & Fatigue Reduction Le Roux, C
Side Effects and Tolerability Because these medications slow digestion and affect gutbrain signaling, they share similar side effects, such as nausea, vomiting, constipation and/or diarrhea
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In addition, semaglutide has been shown to have greater appetite suppressive effects than liraglutide in overweight individuals and so may also be better at suppressing hyperphagia in lipodystrophy (12)
